Three Six Zero is a powerful antioxidant formula designed with ingredients shown to support your dog’s immunity, act as an anti-inflammatory and promote the body’s natural healing properties.

SERVING: One month supply powdered supplement. Give once daily. For optimal results, Three Six Zero should be taken daily for at least 6-8 weeks.

INCLUDES: 1/2 teaspoon scoop
(S) 1.45oz, (M) 2.90oz, (L) 4.35oz

$24.00
$20.40 / monthly
$30.00
$25.50 / monthly
$36.00
$30.60 / monthly

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For too long, efforts in immunity have ignored the fact that a dog’s greatest powers come from their brain. Heroic feats, unconditional love and the ability to persevere. Strengthen the mind and you’ll strengthen the body. Experience uplifting nootropics and balancing adaptogens in the immunity boosting THREE SIX ZERO.

Immunity Ingredients

100% all-natural, human-grade immunity boosting goodness
science-based. research-backed. canine flavor approved.

KEY INGREDIENTS:
Lion’s Mane. Spirulina.

VIEW FULL LIST OF INGREDIENTS
(Proprietary Antioxidant Blend) spirulina, reishi, shiitake, maitake, blueberry, lion's mane, milk thistle, turmeric
💡 HIGHLIGHT:

Lion’s mane has been used in the treatment of oxidative stress due to its therapeutic, antioxidant, and free radical scavenging properties.

references
💡 HIGHLIGHT:

Spirulina’s powerful antioxidant and anti-inflammatory properties help with scavenging free radicals and protecting cells from injury caused by oxidative stress.

references

Research has shown ingredients in Three Six Zero:

  • Support Overall Immunity Health
  • Serve as Anti-Inflammatory
  • Rich in Antioxidants
  • Reduce / Inhibit Oxidative Stress-Related Damage
  • Free Radical Scavenger
  • Lipid Peroxidation Inhibitor
  • References

  • No Artificial Preservatives
  • No Artificial Flavors
  • No Antibiotics or Hormones
  • Not Intended for Birds
    *this is a product for dogs

Reduce stress

Balance mood

Improve cognitive function

What are Nootropics?

Nootropics are supplements that help to improve cognitive function, particularly executive functions, memory, creativity, or motivation. In the same way athletes can better optimize their bodies through diet and training, our brains can also be strengthened.

What are Adaptogens?

Adaptogens are herbs that help balance the stress response system. Adaptogens are flexible in that they adapt to the specific needs of the individual as the body requires— both mental and physical.

REFERENCES

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Jiang, S., Wang, Y., & Zhang, X. (2016). Comparative studies on extracts from hericium erinaceus by different polarity reagents to gain higher antioxidant activities. Experimental and Therapeutic Medicine, 12(1), 513-517.

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Maimes, Steven. (2007). Adaptogens: Herbs for Strength, Stamina, and Stress Relief.

Panossian, Alexander & Rebecca, H & Kadioglu, O & Georg, W & Efferth, Thomas. (2013). Understanding adaptogens: new evidence on their possible effectiveness in stress-induced and ageing-associated disorders from a DNA microarray study of neuroglia cells. Planta Medica. 79. 10.1055/s-0033-1352341.

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Peterson, C. T., Vaughn, A. R., Sharma, V., Chopra, D., Mills, P. J., Peterson, S. N., & Sivamani, R. K. (2018). Effects of turmeric and curcumin dietary supplementation on human gut microbiota: A double-blind, randomized, placebo-controlled pilot study. Journal of Evidence-Based Integrative Medicine, 23, 2515690X18790725-2515690X18790725. doi:10.1177/2515690X18790725 

Sarraf, Payam & Parohan, Mohammad & Javanbakht, mohammad hassan & Ranji-Burachaloo, Sakineh & Djalali, Mahmoud. (2019). Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: A systematic review and dose–response meta-analysis of randomized controlled trials. Nutrition Research. 69. 10.1016/j.nutres.2019.05.001.

Kulkarni, S. K., & Dhir, A. (2010). An overview of curcumin in neurological disorders. Indian journal of pharmaceutical sciences, 72(2), 149–154. doi:10.4103/0250-474X.65012

Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G. M., … Cho, S. G. (2017). Correlation between Oxidative Stress, Nutrition, and Cancer Initiation. International journal of molecular sciences, 18(7), 1544. doi:10.3390/ijms18071544

Fedoce, A. D. G., Ferreira, F., Bota, R. G., Bonet-Costa, V., Sun, P. Y., & Davies, K. J. (2018). The role of oxidative stress in anxiety disorder: cause or consequence?. Free radical research, 52(7), 737-750.

Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity. Pharmaceuticals, 3(1), 188-224.

Wu, Q., Liu, L., Miron, A., Klímová, B., Wan, D., & Kuča, K. (2016). The antioxidant, immunomodulatory, and anti-inflammatory activities of spirulina: An overview. Archives of Toxicology, 90(8), 1817-1840. doi:10.1007/s00204-016-1744-5 

Álvarez-González, I., Islas-Islas, V., Chamorro-Cevallos, G., Barrios, J. P., Paniagua, N., Vásquez-Garzón, V.,R., . . . Madrigal-Bujaidar, E. (2015). Inhibitory effect of spirulina maxima on the azoxymethane-induced aberrant colon crypts and oxidative damage in mice. Pharmacognosy Magazine, 11, S619-S624. doi:10.4103/0973-1296.172973 

Aissaoui, O., Amiali, M., Bouzid, N., Belkacemi, K., & Bitam, A. (2017). Effect of spirulina platensis ingestion on the abnormal biochemical and oxidative stress parameters in the pancreas and liver of alloxan-induced diabetic rats. Pharmaceutical Biology, 55(1), 1304-1312. doi:10.1080/13880209.2017.1300820 

Khatua, S., Paul, S., & Acharya, K. (2013). Mushroom as the Potential Source of New Generation of Antioxidant: A Review. Research Journal of Pharmacy and Technology, 6:5, 496-505.

Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist- Tymchuk MR, Shukitt-Hale B, and Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem 58: 3996–4000, 2010.

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Liu, Bo & Liu, Weiwei & Liu, Panwen & Liu, Xiumin & Song, Xiaoyu & Hayashi, Toshihiko & Onodera, Satoshi & Ikejima, Takashi. (2019). Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence. Neurochemical Research. 44. 10.1007/s11064-019-02816-2.

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., & Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. International journal of molecular sciences, 16(10), 24673-24706

Guggenheim, A. G., Wright, K. M., & Zwickey, H. L. (2014). Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integrative medicine (Encinitas, Calif.), 13(1), 32–44.

Chang, H. C., Yang, H. L., Pan, J. H., Korivi, M., Pan, J. Y., Hsieh, M. C., … & Hseu, Y. C. (2016). Hericium erinaceus inhibits TNF-α-induced angiogenesis and ROS generation through suppression of MMP-9/NF-κB signaling and activation of Nrf2-mediated antioxidant genes in human EA. hy926 endothelial cells. Oxidative medicine and cellular longevity, 2016.

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Woon Yong Choi, Do Hyung Kang, and Hyeon Yong Lee, “Effect of Fermented Spirulina maxima Extract on Cognitive-Enhancing Activities in Mice with Scopolamine-Induced Dementia,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, Article ID 7218504, 9 pages, 2018.

Joanna L. Bowtell, Zainie Aboo-Bakkar, Myra E. Conway, Anna-Lynne R. Adlam, Jonathan Fulford. 2017. Enhanced task- related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Applied Physiology, Nutrition, and Metabolism 42:7, 773-779.

Harrabi, S., Ferchichi, A., Bacheli, A., & Fellah, H. (2018). Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages. Lipids in health and disease, 17(1), 82.

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Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity. Pharmaceuticals, 3(1), 188-224.

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This product is not intended to diagnose, treat, cure, or prevent any disease. Safe use in pregnant animals or animals intended for breeding has not been proven. If animal’s condition worsens or does not improve, stop product administration and consult with your veterinarian.

Warnings: For animal use only. Keep out of reach of children and other animals. In case of accidental overdose, contact a health professional immediately.